Jurgen Klopp has made nine changes to the side that faced Chelsea in midweek, with Virgil van Dijk and Jordan Henderson amongst the inclusions at Stamford Bridge.
The Reds travel to London, hoping to make amends for their 2-1 loss to Maurizio Sarri's side in the Carabao Cup on Wednesday.
Klopp had made eight changes from the side that beat Southampton 3-0 at Anfield last weekend, with the likes of Simon Mignolet, Nathaniel Clyne, Fabinho and Alberto Moreno getting their first start of the campaign.
The manager makes __ changes for the Reds' second meeting with Chelsea, with the Reds restoring some key players to their line-up.
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Alisson Becker replaces Mignolet in goal, whilst Trent Alexander-Arnold and van Dijk have recovered from injury to partner Joe Gomez and Andy Robertson in defence.
Henderson and Gini Wijnaldum return from the off, whilst James Milner retains his place in midfield.
In attack, Mohamed Salah and Roberto Firmino replace Xherdan Shaqiri and Daniel Sturridge, whilst Sadio Mane continues from the left hand side.
Liverpool's summer arrivals of Naby Keita, Fabinho and Shaqiri are all on the bench, having started the League Cup tie on Wednesday.
Liverpool: Alisson, Alexander-Arnold, Gomez, Van Dijk, Robertson, Henderson, Milner, Wijnaldum, Mane, Salah, Firmino.
Substitutes: Mignolet, Moreno, Matip, Fabinho, Keita, Shaqiri, Sturridge.
Chelsea: Kepa, Azpilicueta, Luiz, Rudiger, Alonso, Jorginho, Kante, Kovacic, Willian, Giroud, Hazard.
Substitutes: Caballero, Zappacosta, Cahill, Moses, Fabregas, Barkley, Morata.